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国际呼吸杂志

创刊年:1981年

刊   期:半月刊

主   编:阎锡新

主   任:张雷

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邮发 代号:18-12

中国连续出版物号:ISSN 1673-436X

CN 13-1368/R

2017 年   第 37 卷   第 8 期   半月刊

MiR-155与肺部疾病的研究进展

李男 李云霞 加慧 娄琳 夏书月

【文章下载】

  [摘要] 摘要:miRNAs(microRNA)是一类高度保守的短链非编码RNA,稳定存在于人体的各种体液中,通过碱基互补配对的方式识别靶mRNA,调控基因表达,参与细胞生长、分化、周期、凋亡等多个生物学过程。miR-155(microRNA-155)作为miRNAs的重要成员之一,参与调控多种不同的细胞功能,如造血、免疫应答、病毒感染、炎症反应等。大量的研究证明,miR-155在肺部疾病的发生发展中起到了重要的作用。其通过调节靶向mRNA以及介导多种细胞因子的表达来参与如肺癌、哮喘、肺炎、肺结核、急性肺损伤及肺纤维化等肺部疾病的发展形成。本文就miR-155与肺部疾病关系的研究进展作进一步阐述,希望miR-155可以为肺部疾病的诊断及治疗提供新的方向。

  [Abstract] [Abstract]mirRNAs(microRNA) is a kind of highly conservative short chains of non-coding RNA, Stably existing in various kinds of body fluids of the body, which regulates expression of gene and participates in biological process in cell growth, differentiation, cycle, apoptosis and others by identify target mRNA complementary base pairing way. As one of the important members of microRNAs, MiR - 155(microRNA-155) participates in the regulation of a variety of cellular functions, such as hematopoiesis, immune response, virus infection, inflammation, etc. A large number of studies have shown that miR-155 plays an important part in the development of lung disease, which participates in the formation and development of lung diseases, such as lung cancer, asthma, pneumonia, tuberculosis, acute lung injury,pulmonary fibrosis and so on, by regulating the target mRNA and mediating the expression of a variety of cytokines . The article illustrates further about the research progress of the relationship between miR-155 and lung diseases, and we hope that miR - 155 can offer a new direction for diagnosis and treatment of lung diseases.

  [关键词] miRNAs ; miR-155 ; 肺部疾病;

  [Key words] miRNAs ; miR-155 ; lung disease ;

  [中图分类号]

  [DOI]

  [基金项目]辽宁省教育厅计划项目 (L2014419);沈阳市科学技术计划项目 (F16-156-9-00)

  [作者简介]

  [作者单位] 沈阳医学院附属中心医院呼吸内科

【参考文献】