位置:首页>过刊目录>正文

检索期刊
刊物信息
杂志封面

国际呼吸杂志

创刊年:1981年

刊   期:半月刊

主   编:阎锡新

主   任:张雷

地   址:石家庄市中山东路361号

邮   编:050017

电   话:0311-86266873

E- mail:guojihuxi@vip.163.com

网   址:www.guojihuxi.com

邮发 代号:18-12

中国连续出版物号:ISSN 1673-436X

CN 13-1368/R

2017 年   第 37 卷   第 8 期   半月刊

肺癌的免疫治疗进展

黄萍萍 赵大海

【文章下载】

  [摘要] 目前肺癌的治疗手段是以手术、放疗、化疗和靶向治疗为主的综合治疗,虽然患者的生存期已明显延长,但至今仍是全世界癌症相关死因的主要原因。不断揭示肺癌新的发病机制、探讨新的治疗策略,仍是该领域专家需要共同面对的世界性难题。早期的研究已经初步证明多种肿瘤疫苗、免疫检查点抑制剂、过继性免疫等对肺癌的有效性,目前部分研究已进入Ⅲ期临床,PD-1、PD-L1等免疫检查点抑制剂已批准进入临床并取得理想的效果,随着临床研究的不断开展,越来越多的数据表明,在肺癌的个体化、整体化的治疗策略中适时介入免疫治疗将使更多的肺癌患者获益。

  [Abstract] At present,the main therapies of lung cancer is comprehensive treatment which included surgery, radiotherapy, chemotherapy and targeted therapy.Although the overall survival is significantly prolonged,it is still the main cause of cancer-related death around the world.Constantly revealing new pathogenesis of lung cancer and exploring new therapeutic strategies are still the worldwide problem which experts in the field face together.Early researches has preliminarily proved the effectiveness of a wide variety of tumor vaccines,immune checkpoint inhibitors and adoptive immune response, and part of them has entered the phase III clinical trials.PD-1,PD-L1 and other immune checkpoint inhibitors have been approved for clinical treatment and achieved satisfactory results.With the development of clinical research,more date suggests that the timely intervention of immunotherapy with individualized and integrative therapeutic strategies will benefit more patients.

  [关键词] 肺癌;免疫治疗;肿瘤疫苗;免疫检查点;过继性免疫

  [Key words] Lung cancer; Immunotherapy; Tumor vaccines; Immune checkpoints; Adoptive immune response

  [中图分类号]

  [DOI]

  [基金项目]

  [作者简介]

  [作者单位] 安 徽 医 科 大 学 第 二 附 属 医 院 呼 吸 内科

【参考文献】